76 research outputs found
Perception of Motion and Architectural Form: Computational Relationships between Optical Flow and Perspective
Perceptual geometry refers to the interdisciplinary research whose objectives
focuses on study of geometry from the perspective of visual perception, and in
turn, applies such geometric findings to the ecological study of vision.
Perceptual geometry attempts to answer fundamental questions in perception of
form and representation of space through synthesis of cognitive and biological
theories of visual perception with geometric theories of the physical world.
Perception of form, space and motion are among fundamental problems in vision
science. In cognitive and computational models of human perception, the
theories for modeling motion are treated separately from models for perception
of form.Comment: 10 pages, 13 figures, submitted and accepted in DoCEIS'2012
Conference: http://www.uninova.pt/doceis/doceis12/home/home.ph
Mathematical Analysis and Computational Integration of Massive Heterogeneous Data from the Human Retina
Modern epidemiology integrates knowledge from heterogeneous collections of
data consisting of numerical, descriptive and imaging. Large-scale
epidemiological studies use sophisticated statistical analysis, mathematical
models using differential equations and versatile analytic tools that handle
numerical data. In contrast, knowledge extraction from images and descriptive
information in the form of text and diagrams remain a challenge for most
fields, in particular, for diseases of the eye. In this article we provide a
roadmap towards extraction of knowledge from text and images with focus on
forthcoming applications to epidemiological investigation of retinal diseases,
especially from existing massive heterogeneous collections of data distributed
around the globe.Comment: 9 pages, 3 figures, submitted and accepted in Damor2012 conference:
http://www.uninova.pt/damor2012/index.php?page=author
The Pafah1b Complex Interacts with the Reelin Receptor VLDLR
Reelin is an extracellular protein that directs the organization of cortical structures of the brain through the activation of two receptors, the very low-density lipoprotein receptor (VLDLR) and the apolipoprotein E receptor 2 (ApoER2), and the phosphorylation of Disabled-1 (Dab1). Lis1, the product of the Pafah1b1 gene, is a component of the brain platelet-activating factor acetylhydrolase 1b (Pafah1b) complex, and binds to phosphorylated Dab1 in response to Reelin. Here we investigated the involvement of the whole Pafah1b complex in Reelin signaling and cortical layer formation and found that catalytic subunits of the Pafah1b complex, Pafah1b2 and Pafah1b3, specifically bind to the NPxYL sequence of VLDLR, but not to ApoER2. Compound Pafah1b1(+/−);Apoer2(−/−) mutant mice exhibit a reeler-like phenotype in the forebrain consisting of the inversion of cortical layers and hippocampal disorganization, whereas double Pafah1b1(+/−);Vldlr(−/−) mutants do not. These results suggest that a cross-talk between the Pafah1b complex and Reelin occurs downstream of the VLDLR receptor
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